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Chicken Alfredo Spaghetti Squash Dish

Chicken Alfredo Spaghetti Squash Casserole Recipe

This Chicken Alfredo Spaghetti Squash Casserole combines the creamy indulgence of Alfredo sauce with the low-carb benefits of spaghetti squash for a healthy, satisfying meal.
Perfect for weeknight dinners or meal prep, it’s easy to make, loaded with flavor, and customizable to suit dietary needs. With layers of tender squash, juicy chicken, and cheesy goodness, it’s a crowd-pleaser your family will love.
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Prep Time 20 minutes
Cook Time 50 minutes
Total Time 1 hour 10 minutes
Course Main Course
Cuisine American, Italian
Servings 6 Servings
Calories 350 kcal

Ingredients
  

Main Ingredients:

  • 2 medium spaghetti squash about 3–4 pounds total
  • 3 cups cooked chicken shredded or diced (e.g., rotisserie chicken)
  • 2 cups Alfredo sauce homemade or store-bought
  • 1 cup mozzarella cheese shredded
  • ½ cup Parmesan cheese grated

Seasonings and Garnishes:

  • 1 tsp garlic powder
  • 1 tsp Italian seasoning
  • Salt and pepper to taste
  • 1 tbsp olive oil for roasting squash
  • Fresh parsley or basil chopped (optional garnish)

Optional Additions:

  • 1 cup steamed broccoli optional
  • 1 cup sautéed mushrooms optional

Instructions
 

Prepare the Spaghetti Squash

  • Preheat Oven: Preheat your oven to 400°F (200°C).
  • Cut and Clean: Slice the spaghetti squash in half lengthwise. Scoop out the seeds with a spoon.
  • Season and Roast: Drizzle the cut sides with olive oil, then sprinkle with salt and pepper. Place cut-side down on a baking sheet.
  • Roast: Bake for 30–40 minutes until the squash is tender and the skin pierces easily with a fork.
  • Shred: Let it cool slightly, then use a fork to scrape out the strands of squash into a bowl. Set aside.

Prepare the Alfredo Sauce (If Homemade)

  • Melt 2 tablespoons of butter in a saucepan over medium heat.
  • Add 2 minced garlic cloves and sauté until fragrant.
  • Stir in 1 cup of heavy cream and simmer for 3–4 minutes.
  • Whisk in ¾ cup grated Parmesan cheese until smooth.
  • Season with salt, pepper, and a pinch of nutmeg (optional).

Assemble the Casserole

  • Preheat the oven to 375°F (190°C).
  • Grease a 9x13-inch casserole dish.
  • Spread a thin layer of Alfredo sauce on the bottom of the dish.
  • Layer half of the spaghetti squash strands, half the chicken, and half the Alfredo sauce. Sprinkle with Parmesan.
  • Repeat the layers, finishing with mozzarella cheese on top.

Bake the Casserole

  • Cover the dish with foil and bake for 20 minutes.
  • Remove the foil and bake for another 10–15 minutes, or until the cheese is bubbly and golden.

Serve and Enjoy

  • Garnish with fresh parsley or basil, and serve warm with a side salad or roasted veggies.
Keyword Chicken Alfredo Spaghetti Squash Casserole